Wound healing is a normal physiological function that restores the continuity of tissues after injury. It is a complex process characterized by macroscopic and biochemical events. Considerable advances in molecular technology have enhanced our understanding. Through a knowledge of the processes involved, the clinician should be able to appreciate the role they can play in wound healing and understand current and future treatment options that may modulate the healing process. Particular emphasis is given here to cytokine messaging because this is the key that unlocks the mystery to understanding wound healing. This chapter considers the following: Phases of wound healing; Contraction; Maturation; and Wound strength.