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Radiation therapy of the nervous system

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Abstract

With the common use of computed tomography (CT) and magnetic resonance imaging (MRI) for assessing brain and spinal cord disease, more informed decisions can be made regarding potential therapeutic interventions. This chapters deals with prescribing a radiation dose, reported studies, palliative irradiation, future directions.

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/content/chapter/10.22233/9781910443125.chap24

Figures

Image of 24.1
24.1 Sagittal T2-weighted MR images of three different brain tumours that have similar characteristics. The lesions are all reasonably well defined, isointense to hyperintense compared with the surrounding parenchyma, and mass like. Grade 2 oligodendroglioma. Meningioma. Choroid plexus papilloma. (Courtesy of S Platt)
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24.2 Cumulative probability of survival as a function of time after treatment for canine meningioma treated with surgery alone (black line) or surgery followed by irradiation (blue line). Median survival times are 7.0 and 16.5 months, respectively, suggesting a role for postoperative irradiation in canine meningioma patients. *= censored data point. (Reproduced from with permission from the )
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24.3 Progression-free survival (PFS) as a function of time after treatment for canine meningioma based on the proliferative capacity of the tumour. Survival times of dogs with rapidly proliferating tumours (blue line) are shorter than those of dogs with slowly proliferating tumours (black line). Proliferative capacity was based on immunohistochemical quantification of PCNA. (Reproduced from with permission from the )
Image of 24.4
24.4 Progression-free survival (PFS) as a function of time after irradiation of canine pituitary macrotumours. Survival times are shorter in dogs with large tumours (blue line) than in dogs with small tumours (black line). Tumour size was characterized as relative tumour size, defined as the largest tumour area visible on CT or MRI, divided by the area of the cranial cavity at that level. (Reproduced from with permission from the )
Image of 24.5
24.5 Progression-free survival (PFS) as a function of time after irradiation of canine pituitary macrotumours. Survival times are shorter in dogs with endocrinologically inactive tumours (blue line) than in dogs with active tumours (black line). (Reproduced from with permission from the )
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24.6 Survival times of dogs with pituitary masses treated with either radiation therapy (blue line) or left untreated (black line). Radiation treatment was given to 19 dogs and 27 dogs received no treatment. The lines are significantly different (log-rank test: P5 .0039). Censored dogs are indicated by vertical marks. (Reproduced from with permission from the )

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