This session will discuss the general and specific use of immunosuppressive drugs. Although glucocorticoids are normally the first choice for the treatment of many immune-mediated diseases, non-steroidal immunosuppressive therapy is often also required to achieve lasting remission while minimizing steroid-associated side effects. These treatments can be expensive, risky to owners and animals, and require careful management. Proper case selection is essential, which involves a properly confirmed diagnosis, informed owner consent, and a structured monitoring plan. Immunosuppressive therapy should begin promptly once indicated, rather than as a last resort. Selection of the most appropriate treatment is based on evidence from the literature, textbooks and personal experience. Doses in textbooks provide a useful starting point, but each case is different and individualized titration and monitoring are needed. Many of these drugs have specific handling requirements and this includes the careful separation/disposal of excreta. BSAVA members can access client information leaflets (CIL) for guidance.