The administration of drugs to pet rodents poses some unique challenges to the veterinary surgeon. Rodents are routinely used as research laboratory animals and a significant amount of information has been gathered on drug use in different species. Much of this information is not readily available to the general clinician and applies to specific laboratory conditions that do not necessarily correspond to clinical situations in pets. The chapter covers Routes of drug administration; Antibiotics; Antifungal agents; Antiparasitic agents; Topical agents and Miscellaneous agents.