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Disorders of platelet number
/content/chapter/10.22233/9781905319732.chap23
Disorders of platelet number
- Authors: Ann Hohenhaus and Carrie White
- From: BSAVA Manual of Canine and Feline Haematology and Transfusion Medicine
- Item: Chapter 23, pp 201 - 215
- DOI: 10.22233/9781905319732.23
- Copyright: © 2012 British Small Animal Veterinary Association
- Publication Date: January 2012
Abstract
Platelets adhere to injured vascular endothelium in the primary step of haemostasis. Following adherence, platelets are activated and release granules, which recruit additional platelets to the area of injury. Activated platelets aggregate to form a temporary platelet plug. This chapter covers thrombocytopenia; thrombocytosis.
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Figures
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23.1
Petechiae on the medial thigh of a dog. © 2012 British Small Animal Veterinary Association
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23.1
Petechiae on the medial thigh of a dog.
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23.2
Epistaxis in a Cocker Spaniel with thrombocytopenia secondary to administration of levamisole as an immunomodulatory agent. © 2012 British Small Animal Veterinary Association
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23.2
Epistaxis in a Cocker Spaniel with thrombocytopenia secondary to administration of levamisole as an immunomodulatory agent.
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23.4
Diagnostic algorithm for a dog or cat with thrombocytopenia and surface bleeding. aPTT, activated partial thromboplastin time; BMBT, buccal mucosal bleeding time; DIC, disseminated intravascular coagulation; FeLV, feline leukemia virus; FIV, feline immunodeficiency virus; FSP, fibrin split products; IMTP, immune-mediated thrombocytopenia; MPV, mean platelet volume; PT, prothrombin time; TEG, thromboelastography. a High risk of bleeding; platelet products should be available. © 2012 British Small Animal Veterinary Association
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23.4
Diagnostic algorithm for a dog or cat with thrombocytopenia and surface bleeding. aPTT, activated partial thromboplastin time; BMBT, buccal mucosal bleeding time; DIC, disseminated intravascular coagulation; FeLV, feline leukemia virus; FIV, feline immunodeficiency virus; FSP, fibrin split products; IMTP, immune-mediated thrombocytopenia; MPV, mean platelet volume; PT, prothrombin time; TEG, thromboelastography. a High risk of bleeding; platelet products should be available.
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23.5
Surface bleeding in a Dobermann with thrombocytopenia secondary to administration of sulphonamide antibiotic. © 2012 British Small Animal Veterinary Association
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23.5
Surface bleeding in a Dobermann with thrombocytopenia secondary to administration of sulphonamide antibiotic.
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23.6
Photomicrograph (original magnification × 1000) of a blood smear from a Cavalier King Charles Spaniel with macrothrombocytosis. Note that the platelets are nearly as large as the red blood cells. © 2012 British Small Animal Veterinary Association
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23.6
Photomicrograph (original magnification × 1000) of a blood smear from a Cavalier King Charles Spaniel with macrothrombocytosis. Note that the platelets are nearly as large as the red blood cells.
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23.7
Plateletgrams from an automated haematology analyser demonstrating various platelet counts. Each blue dot represents one platelet. The red dots are red blood cells, (a) Canine platelet count = 2 x 109/l. (b) Canine platelet count = 268 x 109/l. (c) Feline platelet count = 765 x 109/l. © 2012 British Small Animal Veterinary Association
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23.7
Plateletgrams from an automated haematology analyser demonstrating various platelet counts. Each blue dot represents one platelet. The red dots are red blood cells, (a) Canine platelet count = 2 x 109/l. (b) Canine platelet count = 268 x 109/l. (c) Feline platelet count = 765 x 109/l.