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Disorders of platelet number

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Abstract

Platelets adhere to injured vascular endothelium in the primary step of haemostasis. Following adherence, platelets are activated and release granules, which recruit additional platelets to the area of injury. Activated platelets aggregate to form a temporary platelet plug. This chapter covers thrombocytopenia; thrombocytosis.

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Figures

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23.1 Petechiae on the medial thigh of a dog.
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23.2 Epistaxis in a Cocker Spaniel with thrombocytopenia secondary to administration of levamisole as an immunomodulatory agent.
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23.4 Diagnostic algorithm for a dog or cat with thrombocytopenia and surface bleeding. aPTT, activated partial thromboplastin time; BMBT, buccal mucosal bleeding time; DIC, disseminated intravascular coagulation; FeLV, feline leukemia virus; FIV, feline immunodeficiency virus; FSP, fibrin split products; IMTP, immune-mediated thrombocytopenia; MPV, mean platelet volume; PT, prothrombin time; TEG, thromboelastography. High risk of bleeding; platelet products should be available.
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23.5 Surface bleeding in a Dobermann with thrombocytopenia secondary to administration of sulphonamide antibiotic.
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23.6 Photomicrograph (original magnification × 1000) of a blood smear from a Cavalier King Charles Spaniel with macrothrombocytosis. Note that the platelets are nearly as large as the red blood cells.
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23.7 Plateletgrams from an automated haematology analyser demonstrating various platelet counts. Each blue dot represents one platelet. The red dots are red blood cells, Canine platelet count = 2 x 10/l. Canine platelet count = 268 x 10/l. Feline platelet count = 765 x 10/l.

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