Blood substitutes

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The designation ‘blood substitute’ is a misnomer, because no solution developed to date possesses all of the properties of blood. ‘Substitute’ products for some of the properties of blood, including the oxygen-carrying ability, volume-expanding property and clotting capability, have been developed and used in animals. This chapter reviews haemoglobin-based oxygen-carrying fluid; erythropoietin; factor VIIa and anti-fibrinolytics.

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36.2 Haemoglobin–oxygen equilibrium. Oxyglobin’s haemoglobin has a lower affinity for oxygen (right-shifted curve) compared with RBCs. The arterio-venous difference in oxygen saturation is similar between RBCs and Oxyglobin. Plasma is poorly saturated with oxygen.
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