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Blood substitutes
/content/chapter/10.22233/9781905319732.chap36
Blood substitutes
- Author: Virginia Rentko
- From: BSAVA Manual of Canine and Feline Haematology and Transfusion Medicine
- Item: Chapter 36, pp 319 - 323
- DOI: 10.22233/9781905319732.36
- Copyright: © 2012 British Small Animal Veterinary Association
- Publication Date: January 2012
Abstract
The designation ‘blood substitute’ is a misnomer, because no solution developed to date possesses all of the properties of blood. ‘Substitute’ products for some of the properties of blood, including the oxygen-carrying ability, volume-expanding property and clotting capability, have been developed and used in animals. This chapter reviews haemoglobin-based oxygen-carrying fluid; erythropoietin; factor VIIa and anti-fibrinolytics.
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36.2
Haemoglobin–oxygen equilibrium. Oxyglobin’s haemoglobin has a lower affinity for oxygen (right-shifted curve) compared with RBCs. The arterio-venous difference in oxygen saturation is similar between RBCs and Oxyglobin. Plasma is poorly saturated with oxygen. © 2012 British Small Animal Veterinary Association
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36.2
Haemoglobin–oxygen equilibrium. Oxyglobin’s haemoglobin has a lower affinity for oxygen (right-shifted curve) compared with RBCs. The arterio-venous difference in oxygen saturation is similar between RBCs and Oxyglobin. Plasma is poorly saturated with oxygen.