Surgical staplers may be used in a wide variety of cutaneous, abdominal, thoracic and other veterinary surgical procedures. Possible advantages of surgical staplers over manual suturing include: Reduction of surgical time (operative and anaesthetic); Reduced tissue trauma/manipulation; Reduction or elimination of surgical contamination; Easy and secure closure of large vessels, vascular pedicles and gastrointestinal, lung, liver and splenic tissue (which is especially useful in areas that are difficult to reach and dissect manually). This chapter deals with Linear staplers; Linear cutter staplers; Circular staplers; Ligate and divide stapler (LDS); Vascular clip applicators; Skin staplers; and Current and future developments.