It is worth defining acupuncture at the start of any discussion of its uses, since the term means different things to different people. Whilst a given drug will have the same formula and same accepted dose rate all over the world, acupuncture look – and feels – different depending on the training, approach and, sometimes, philosophy of whoever is delivering the treatment. This chapter looks at How acupuncture works; The role of acupuncture in veterinary palliative care and rehabilitative medicine; Clinical considerations; and Safety considerations.