1887

Laboratory evaluation of hypothyroidism and hyperthyroidism

image of Laboratory evaluation of hypothyroidism and hyperthyroidism
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Abstract

Hypothyroidism and hyperthyroidism are the most common endocrine disorders of dogs and cats, respectively, and testing for these diseases is frequently carried out in practice. Interpretation relies on a good understanding of thyroid physiology and the myriad factors, other than thyroid disease and including assay methodology, that can affect tests of thyroid function.The chapter looks at physiology of the thyroid gland, laboratory methods for assessment of thyroid function, hypothyroidism and hyperthyroidism. This section also contains a selection of case examples.

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Figures

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17.1 Histological appearance of healthy canine thyroid tissue. Note the follicular architecture. (Haematoxylin and eosin stain)
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17.2 The hypothalamic–pituitary–thyroid–extrathyroid axis, demonstrating the interactions among the various factors controlling thyroid function. TRH = thyrotropin-releasing hormone; TSH = thyroid-stimulating hormone (thyrotropin); T3 = triiodothyronine; T4 = thyroxine; + = stimulation; – = inhibition.
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17.13 The relationship of mortality to serum total T4 concentrations in 107 cats with a variety of non-thyroidal illnesses. Drawn by S.J. Elmhurst BA Hons (www.livingart.org.uk) and reproduced with her permission.

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