The pancreas is composed of a body and two lobes or limbs; the body separates the right and left lobes and is located just ventral to the portal vein, between the pylorus and the proximal descending duodenum. The right lobe runs in a caudal direction in the mesoduodenum, near or in contact with the body wall, just ventral to the right kidney. The left pancreatic lobe is located caudal to the greater curvature of the stomach, cranial to the transverse colon, and extends laterally to terminate close to the cranial pole of the left kidney. In the cat the left lobe may extend dorsally, caudal to the spleen. The pancreas is vasularized by branches of the cranial and caudal pancreaticoduodenal arteries, and by the pancreatic branch of the splenic artery. Venous drainage of the right lobe is mostly through the caudal pancreaticoduodenal vein, the last tributary od the classic mesenteric vein. The left lobe drains into the splenic vein. There are two excretory ducts: the accessory pancreatic duct, which terminates in the duodenum at the minor duodenal papilla; and the pancreatic duct, which terminates at the major duodenal papilla together with the common bile duct. This chapter considers Overview of anatomy; Radiographic detection of pancreatic disease; Ultrasonography; Overview of additional imaging modalities; and Pancreatic diseases.