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The most common cause of severe thrombocytopenia is immune-mediated thrombocytopenia (IMTP). IMTP is defined by a low platelet count, normal bone marrow function, the absence of other causes of thrombocytopenia and response to immunosuppressive therapy. This chapter covers pathogenesis of primary and secondary IMTP; acquired amegakaryocytic thrombocytopenia; causes of secondary IMTP; clinical approach to primary IMTP; management of IMTP; prognosis.
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