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An approach to keratinization disorders
/content/chapter/10.22233/9781905319886.chap6
An approach to keratinization disorders
- Author: Karen L. Campbell
- From: BSAVA Manual of Canine and Feline Dermatology
- Item: Chapter 6, pp 46 - 52
- DOI: 10.22233/9781905319886.6
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Copyright:
- Publication Date: September 2012
Abstract
PLEASE NOTE A NEW 4TH EDITION HAS BEEN PUBLISHED AND IS AVAILABLE IN THE LIBRARY AND IN PRINT
Keratinization is the process by which epithelial cells in the skin differentiate progressively from basal cells attached to the basement membrane into fully keratinized cells that are exfoliated from the skin surface. Keratinization is a complex process that is genetically programmed and regulated by the interactions of a myriad of intrinsic and extrinsic factors. Cornification of the skin also involves the formation of a lipid-rich intercellular matrix that serves as a mortar between the stacks of anucleate, flattened keratinocytes in the stratum corneum. This lipid matrix serves as a permeability barrier for the skin, regulates desquamation and has antimicrobial activity. The chapter looks at: Differential diagnosis; Clinical approach; and Treatment.
/content/chapter/10.22233/9781905319886.chap6
Figures
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6.1
(a) Seborrhoea sicca in a hypothyroid mixed-breed dog. (b) Numerous scales have accumulated in the hair coat of this dog with seborrhoea sicca secondary to hypothyroidism. (c) Greasy accumulations on the ventral neck of a dog with seborrhoea oleosa. (d) Seborrhoeic dermatitis in a mixed-breed dog with pemphigus foliaceus. (e) Follicular casts on the back of a Standard Poodle with sebaceous adenitis. © 2012 British Small Animal Veterinary Association
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6.1
(a) Seborrhoea sicca in a hypothyroid mixed-breed dog. (b) Numerous scales have accumulated in the hair coat of this dog with seborrhoea sicca secondary to hypothyroidism. (c) Greasy accumulations on the ventral neck of a dog with seborrhoea oleosa. (d) Seborrhoeic dermatitis in a mixed-breed dog with pemphigus foliaceus. (e) Follicular casts on the back of a Standard Poodle with sebaceous adenitis.
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6.3
Lethal acrodermatitis. (a) Bull Terrier puppies. (b) Splayed toes of an affected Bull Terrier puppy. © 2012 British Small Animal Veterinary Association
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6.3
Lethal acrodermatitis. (a) Bull Terrier puppies. (b) Splayed toes of an affected Bull Terrier puppy.
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6.4
Ear margin seborrhoea. © 2012 British Small Animal Veterinary Association
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6.4
Ear margin seborrhoea.
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6.5
West Highland White Terrier with epidermal dysplasia and Malassezia dermatitis. © 2012 British Small Animal Veterinary Association
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6.5
West Highland White Terrier with epidermal dysplasia and Malassezia dermatitis.
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6.6
Non-epidermolytic ichthyosis. (a) Large scales on the side of a Golden Retriever. (b) Tightly adherent scales on the ventral abdomen and inguinal region of a 10-week-old American Bulldog. © 2012 British Small Animal Veterinary Association
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6.6
Non-epidermolytic ichthyosis. (a) Large scales on the side of a Golden Retriever. (b) Tightly adherent scales on the ventral abdomen and inguinal region of a 10-week-old American Bulldog.
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6.7
Alaskan Malamute with zinc-responsive dermatitis syndrome I. © 2012 British Small Animal Veterinary Association
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6.7
Alaskan Malamute with zinc-responsive dermatitis syndrome I.
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6.8
Nasal hyperkeratosis in a Boston Terrier. © 2012 British Small Animal Veterinary Association
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6.8
Nasal hyperkeratosis in a Boston Terrier.
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6.9
Sebaceous adenitis. (a) Beagle. Note the polycyclic pattern of alopecia on the ear pinna. (b) Vizsla. Note the polycyclic pattern of alopecia. © 2012 British Small Animal Veterinary Association
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6.9
Sebaceous adenitis. (a) Beagle. Note the polycyclic pattern of alopecia on the ear pinna. (b) Vizsla. Note the polycyclic pattern of alopecia.
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6.10
Feline acne. Note the dark keratinous debris and comedones on the chin. © 2012 British Small Animal Veterinary Association
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6.10
Feline acne. Note the dark keratinous debris and comedones on the chin.
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6.11
Idiopathic facial dermatitis in a 1-year-old Persian. © 2012 British Small Animal Veterinary Association
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6.11
Idiopathic facial dermatitis in a 1-year-old Persian.