Clinical pathology

Petra Wesche

doi:10.22233/9781910443217.9

Clinical pathology

British Small Animal Veterinary Association , 124 (2014); https://doi.org/10.22233/9781910443217.9

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Clinical pathology

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Author: Petra Wesche
From: BSAVA Manual of Rabbit Medicine
Item: Chapter 9, pp 124 - 137
DOI: 10.22233/9781910443217.9
Copyright: © 2014 British Small Animal Veterinary Association
Publication Date: February 2014

Abstract

This chapter addresses haematology, blood biochemistry, urinalysis, cerebrospinal fluid, serology, bone marrow and cytology in relation to rabbits.

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Figures

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9.2

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9.2 Erythrocyte polychromasia and anisocytosis are a normal finding on rabbit blood smears.

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9.3

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9.3 A small lymphocyte.

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9.4

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9.4 A heterophil; note the rod-shaped granules.

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9.5

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9.5 An eosinophil; note the more prominent rounded granules.

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9.6

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9.6 A monocyte.

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9.7

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9.7 Basophil (B) and heterophil (H); also present are platelet clumps.

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9.14

Fine-needle aspirate from a case of steatitis in the dewlap of a rabbit. There are abundant erythrocytes, with a few macrophages and a few heterophils. As there is no fat on this smear, a diagnosis of steatitis would not be possible from it alone, only chronic active inflammation. (May–Grünwald Giemsa; original magnification X400) © Chris Knott. © 2014 British Small Animal Veterinary Association

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9.14 Fine-needle aspirate from a case of steatitis in the dewlap of a rabbit. There are abundant erythrocytes, with a few macrophages and a few heterophils. As there is no fat on this smear, a diagnosis of steatitis would not be possible from it alone, only chronic active inflammation. (May–Grünwald Giemsa; original magnification X400) © Chris Knott.

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9.15

Fine-needle aspirate from a cutaneous mass. Apart from erythrocytes (probably contamination during sampling) it consists largely of keratin squames (nucleated and non-nucleated) and clumps of keratinous debris. This is typical of a keratinizing cystic lesion such as an epidermal cyst, infundibular keratinizing acanthoma, or one of the various benign skin adnexal tumours such as trichofolliculoma, trichoepithelioma or pilomatrixoma. (May–Grünwald Giemsa; original magnification X200) © Chris Knott. © 2014 British Small Animal Veterinary Association

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9.15 Fine-needle aspirate from a cutaneous mass. Apart from erythrocytes (probably contamination during sampling) it consists largely of keratin squames (nucleated and non-nucleated) and clumps of keratinous debris. This is typical of a keratinizing cystic lesion such as an epidermal cyst, infundibular keratinizing acanthoma, or one of the various benign skin adnexal tumours such as trichofolliculoma, trichoepithelioma or pilomatrixoma. (May–Grünwald Giemsa; original magnification X200) © Chris Knott.

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9.16

(a) Fine-needle aspirate from a subcutaneous cystic swelling. There are abundant moderately cohesive cells, which look at first sight somewhat like adipocytes from a lipoma, but they are smaller. These are very suggestive of mesenchymal stellate cells from the larval cestode in a coenurus cyst (probably Taenia serialis). (May–Grünwald Giemsa; original magnification X200) (b) Histology of the lesion, which was removed a few days after aspiration, shows multiple larval cestodes within the coenurus. Note the hooklets on the protoscolex and the abundant parenchymal stellate cells. (H&E; original magnification X100) © Chris Knott. © 2014 British Small Animal Veterinary Association

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9.16 (a) Fine-needle aspirate from a subcutaneous cystic swelling. There are abundant moderately cohesive cells, which look at first sight somewhat like adipocytes from a lipoma, but they are smaller. These are very suggestive of mesenchymal stellate cells from the larval cestode in a coenurus cyst (probably Taenia serialis). (May–Grünwald Giemsa; original magnification X200) (b) Histology of the lesion, which was removed a few days after aspiration, shows multiple larval cestodes within the coenurus. Note the hooklets on the protoscolex and the abundant parenchymal stellate cells. (H&E; original magnification X100) © Chris Knott.

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9.17

(a) The typical appearance of a fine-needle aspirate from a lipoma, showing a sheet of ruptured and collapsed adipocytes. (b) This aspirate contains a few intact adipocytes. (May–Grünwald Giemsa; original magnification X400) © Chris Knott. © 2014 British Small Animal Veterinary Association

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9.17 (a) The typical appearance of a fine-needle aspirate from a lipoma, showing a sheet of ruptured and collapsed adipocytes. (b) This aspirate contains a few intact adipocytes. (May–Grünwald Giemsa; original magnification X400) © Chris Knott.