Diseases of the liver

image of Diseases of the liver
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The liver lies in the cranial abdomen, between the diaphragm and the stomach, and is made up of four lobes and a gall bladder. The gall bladder is linked to the duodenum via a common bile duct, with a slightly different anatomical arrangement in cats and dogs. The lateral parts of the right and left liver lobes are seen on lateral abdominal radiographs in dogs and cats as the caudoventral edge of the liver shadow under the costal arch. This chapter examines Anatomy; Function; Differences between dogs and cats; Investigating liver disease; Pathophysiology of acute and chronic liver disease; Acute liver disease; Chronic liver disease; and Treatment of chronic liver disease.

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24.1 Ventral view of the structure of the canine liver. (Reproduced from with permission from Blackwell Publishing)
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24.2 Diagrammatic illustration of the structure of the liver. (a) Hepatic lobule. (b) Diagram of the anatomy of the space of Disse and canaliculi. (Reproduced from with permission from Blackwell Publishing)
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24.4 Diagrammatic illustration of the function of the liver. (a) Schematic drawing of one cord of hepatocytes showing functional zonation. (b) Schematic drawing of zonal distribution in hepatic acinus. (Reproduced from with permission from Blackwell Publishing)
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24.14 Portosystemic shunts. (a) Diagramatic representation of a congenital portosystemic shunt. (b) Multiple acquired shunts develop if the pressure in the portal vein is greater than the pressure in the vena cava. (c) Gross appearance of acquired portosystemic shunts joining the caudal vena cava in the region of the right kidney. (Photography by Bryden Stanley.) (Reproduced from Watson (1997) with permission from .)
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24.18 Cytological appearance of severe hepatic lipidosis in a cat. Note the great accumulation of fat globules in the hepatocytes. Giemsa stain; original magnifcation x1000. (Courtesy of Elizabeth Villiers)
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24.19 Cat with hepatic lipidosis and gastrostomy tube in place.
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24.20 Bedlington Terrier with copper storage disease.
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24.21 Copper granules in the hepatocytes of a Bedlington Terrier with copper storage disease. Giemsa stain; original magnification x1000. (Courtesy of Elizabeth Villiers)
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24.28 Gross post-mortem appearance of liver from a 2-year-old Husky, which had just a 7-day history of anorexia, vomiting and ascites with marked elevation of liver enzymes and bile acids. The final histological diagnosis was poorly differentiated sarcoma, which had probably originated in the spleen.
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