Disseminated intravascular coagulation

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Disseminated intravascular coagulation (DIC) is a complicated and dynamic haemostatic syndrome characterized by simultaneous variable imbalances of several components of the haemostatic system. This chapter covers aetiology of DIC; pathophysiology; biomarkers; diagnosis; treatment.

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30.1 Pathophysiology of disseminated intravascular coagulation (DIC) as proposed by . AT, antithrombin; FDPs, fibrin degradation products; PC, protein C; PS, protein S; TF, tissue factor; TFPI, tissue factor pathway inhibitor; TNF-α, tumour necrosis factor-α.
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30.3 Diagnostic and therapeutic decision tree for patients with disseminated intravascular coagulation (DIC). aPTT, activated partial thromboplastin time; AT, antithrombin; CBC, complete blood count; FDP, fibrin degradation products; PT, prothrombin time; TEG, thromboelastography. Controversial treatment.
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