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Autoimmune and immune-mediated skin disease
/content/chapter/10.22233/9781905319886.chap26
Autoimmune and immune-mediated skin disease
- Author: Hilary A. Jackson
- From: BSAVA Manual of Canine and Feline Dermatology
- Item: Chapter 26, pp 206 - 214
- DOI: 10.22233/9781905319886.26
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Copyright:
- Publication Date: September 2012
Abstract
PLEASE NOTE A NEW 4TH EDITION HAS BEEN PUBLISHED AND IS AVAILABLE IN THE LIBRARY AND IN PRINT
Autoimmune and immune-mediated diseases of the skin are uncommon or rare disorders. The severity can vary from mild localized disease to life-threatening conditions. Many diseases are seen more commonly in certain breeds, suggesting an hereditary predisposition. Diagnosis of such disorders is not always easy and usually relies on biopsy for histopathology. Management should never be instituted until a specific diagnosis has been reached and treatment is often difficult. The chapter focuses on Autoimmune diseases; Immune-mediated diseases; and Treatment.
/content/chapter/10.22233/9781905319886.chap26
Figures
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26.1
(a) Symmetrical crusting on the haired skin and nasal planum of a dog with pemphigus foliaceus. (b) Multifocal crusts on the convex pinna of a dog with drug-induced pemphigus foliaceus. (Courtesy of P Forsythe) © 2012 British Small Animal Veterinary Association
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26.1
(a) Symmetrical crusting on the haired skin and nasal planum of a dog with pemphigus foliaceus. (b) Multifocal crusts on the convex pinna of a dog with drug-induced pemphigus foliaceus. (Courtesy of P Forsythe)
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26.2
Cytology of an intact pustule from a case of pemphigus foliaceus. Note the non-degenerate neutrophils and free-floating acantholytic keratinocytes. (Diff-Quik® stain; original magnification x1000) © 2012 British Small Animal Veterinary Association
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26.2
Cytology of an intact pustule from a case of pemphigus foliaceus. Note the non-degenerate neutrophils and free-floating acantholytic keratinocytes. (Diff-Quik® stain; original magnification x1000)
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26.3
Histology of pemphigus foliaceus. Note the intact subcorneal pustule. (Haematoxylin and eosin stain; original magnification x400) © 2012 British Small Animal Veterinary Association
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26.3
Histology of pemphigus foliaceus. Note the intact subcorneal pustule. (Haematoxylin and eosin stain; original magnification x400)
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26.4
Mucous membrane pemphigoid. Note the ulceration, crusting, cicatricial alopecia and loss of pigment. © 2012 British Small Animal Veterinary Association
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26.4
Mucous membrane pemphigoid. Note the ulceration, crusting, cicatricial alopecia and loss of pigment.
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26.5
Epidermolysis bullosa acquisita in a young Great Dane. Sloughing of the footpads is visible. © 2012 British Small Animal Veterinary Association
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26.5
Epidermolysis bullosa acquisita in a young Great Dane. Sloughing of the footpads is visible.
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26.7
Vesicular cutaneous lupus erythematosus in a Rough Collie. Note the polycyclic, serpigenous ulcerations on the ventral abdomen. (Reproduced from
Jackson and Olivry (2001)
with permission from the publishers) © 2012 British Small Animal Veterinary Association
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26.7
Vesicular cutaneous lupus erythematosus in a Rough Collie. Note the polycyclic, serpigenous ulcerations on the ventral abdomen. (Reproduced from
Jackson and Olivry (2001)
with permission from the publishers)
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26.9
Ischaemic damage to the extremities of a cat with idiopathic vasculitis. © 2012 British Small Animal Veterinary Association
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26.9
Ischaemic damage to the extremities of a cat with idiopathic vasculitis.
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26.10
Vascular infarct of the convex pinna caused by post-vaccination ischaemia. © 2012 British Small Animal Veterinary Association
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26.10
Vascular infarct of the convex pinna caused by post-vaccination ischaemia.
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26.11
Petechiae on the lateral flank associated with Rocky Mountain spotted fever (Rickettsia rickettsii). © 2012 British Small Animal Veterinary Association
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26.11
Petechiae on the lateral flank associated with Rocky Mountain spotted fever (Rickettsia rickettsii).
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26.12
Diascopy: with extravasation the lesions fail to blanche with pressure. © 2012 British Small Animal Veterinary Association
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26.12
Diascopy: with extravasation the lesions fail to blanche with pressure.
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26.13
Multifocal erosions associated with erythema multiforme. © 2012 British Small Animal Veterinary Association
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26.13
Multifocal erosions associated with erythema multiforme.