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Cutaneous lesions are prominent in many systemic and deep infectious diseases. When patients present with clinical signs that are compatible with such disorders, a thorough history, especially a travel history, is crucial because many diseases are endemic to certain geographical locations. It should be noted that many of the diseases discussed in this chapter are exotic to the UK. Some of these diseases are also contagious, so the existence of any affected in-contact animals needs to be noted. When gathering samples from these patients, it is recommended that precautions be taken, such as wearing gloves to avoid any potentially infectious agents. A complete physical examination, including all organ systems, will help to identify those infections that commonly affect multiple organ systems. The chapter covers the following topics: Bacterial infections; Fungal infections; Oomycete infections; Parasitic infections; and Other infections.