image of Acromegaly
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Several specific pathological conditions in dogs and cats can result in excess production of growth hormone as well as resulting in excess production of insulin-like growth factor-1. This combination causes a broad range of adverse effects, reflecting the different biological functions of both these hormones. Ultimately, chronic excess exposure can lead to the clinical syndrome of acromegaly. Acromegaly is now becoming an increasingly important differential diagnosis when dealing with insulin-resistant diabetes in cats.

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5.2 Mandibular enlargement resulting in prognathism and thickening of the bony ridges of the skull in a cat with acromegaly. While a typical finding, this is not seen in all acromegalic cats.
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5.3 Widening of interdental spaces due to chronic exposure to excess growth hormone in a dog with acromegaly.
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5.4 Cross-section of the myocardium from an acromegalic cat, showing generalized hypertrophy.
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5.5 Macroscopic abnormalities, specifically pancreatic enlargement and cysts, in a pancreas from a cat with acromegaly.
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5.6 Post-mortem and CT findings in an acromegalic cat. The white arrows (in both pictures) indicate the enlarged pituitary gland. The black arrow indicates the optic chiasm, illustrating the rare potential for visual abnormalities to occur when a large pituitary tumour is present.
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