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Hyperparathyroidism

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Abstract

PLEASE NOTE. THE NEW 5TH EDITION OF THE BSAVA MANUAL OF ENDOCRINOLOGY IS NOW AVAILABLE HERE.

Primary hyperparathyroidism is an uncommon disease in dogs and is rare in cats but must still be considered as a possible cause of hypercalcaemia, particularly in an older, relatively asymptomatic dog. This chapter will discuss all recognized forms of hyperparathyroidism and their appropriate management strategies. Case examples: 10-year old male neutered Keeshond, 23.5 kg; 11-year-old male Beagle, 17 kg

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Figures

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6.1 Schematic representation of the anatomical position of the parathyroid glands.
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6.2 Histological appearance of the parathyroid glands from a healthy dog, showing cords or nests of cells around capillaries. H&E stain; bar = 50 µm. (Courtesy of Fernando Constantino-Casas)
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6.3 Calcium homeostasis. The release of PTH causes increased uptake of calcium in the kidney and gut, and mobilization from the skeleton.
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6.5 The skeletal calcium acts as a reservoir, so that calcium can be stored or mobilized, depending on need.
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6.7 Lateral and ventrodorsal abdominal radiographs showing a large nephrolith in the left kidney and multiple smaller uroliths.
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6.9 Ultrasonographic image of the ventral neck showing the right thyroid gland (arrow) containing a large, hypoechoic parathyroid nodule (dimensions delineated by dotted lines).
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6.10 Removal of a parathyroid adenoma. The thyroid (dark red) is visible overlying the trachea with a smaller, paler, parathyroid nodule (at tip of cotton bud). (Courtesy of Ed Friend)
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