This chapter describes drugs used non-specifically to manage signs associated with gastrointestinal (GI) and liver diseases, their proposed modes of action, interactions and potential side effects in dogs and cats. Antiemetics, prokinetics, mucosal (cyto)protectants, acid blockers (anti-ulcer drugs), antidiarrhoeals, laxatives and cathartics, immunosuppressive/anti-inflammatory agents and appetite stimulants are discussed.