1887

Calcium aluminosilicate (Bentonite, Hydrated calcium aluminosilicate, Smectite)

This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition
  1. Fournier Q, Serra JC, Williams C and Bavcar S (2021) Chemotherapy-induced diarrhoea in dogs and its management with smectite: Results of a monocentric open-label randomized clinical trial. Veterinary and Comparative Oncology 19, 25–33
  2. Buccigrossi V, Russo C, Guarino A, de Freitas MB and Guarino A (2017) Mechanisms of antidiarrhoeal effects by diosmectite in human intestinal cells. Gut Pathogens 9, 23
  3. Das RR, Sankar J and Naik SS (2015) Efficacy and safety of diosmectite in acute childhood diarrhoea: a meta-analysis. Archives of Disease in Childhood 100, 704–712
  4. Fioramonti J, Droy-Lefaix MT and Bueno L (1987) Changes in gastro-intestinal motility induced by cholera toxin and experimental osmotic diarrhoea in dogs: effects of treatment with an argillaceous compound.Digestion 36, 230–237
  5. Hahn KA and Carpenter RH (2008) Calcium aluminosilicate (CAS) in the treatment of intractable diarrhea in dogs with cancer.Journal of Applied Research in Veterinary Medicine 6, 181–184
  6. Khediri F, Mrad AI, Azzouz M et al. (2011) Efficacy of diosmectite (smecta) in the treatment of acute watery diarrhoea in adults: a multicentre, randomized, double-blind, placebo-controlled, parallel group study.Gastroenterology Research and Practice 2011, 783196
  7. Sturino JM, Pokusaeva K and Carpenter R (2015) Effective sequestration of Clostridium difficile protein toxins by calcium Aluminosilicate.Antimicrobial Agents and Chemotherapy 59, 7178–7183
  8. Weese JS, Cote NM and deGannes RV (2003) Evaluation of in vitro properties of di-tri-octahedral smectite on clostridial toxins and growth.Equine Veterinary Journal 35, 638–641
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