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  3. Imepitoin
Imepitoin
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Imepitoin

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This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition. 
  1. Engel O, Müller HW, Klee R, Francke B and Mills DS (2019) Effectiveness of imepitoin for the control of anxiety and fear associated with noise phobia in dogs. Journal of Veterinary Internal Medicine 33, 2675–2684
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  2. Gallucci A, Gagliardo T, Menchetti M et al.(2015)Efficacy of imepitoin as first choice drug in treatment of 53 naïve dogs affected by idiopathic epilepsy. In: Proceedings of the 28th Symposium ESVN-ECVN. Journal of Veterinary Internal Medicine 30, 446
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  3. Rundfeldt C ,Tipold A andLöscher W (2015)Efficacy, safety, and tolerability of imepitoin in dogs with newly diagnosed epilepsy in a randomized controlled clinical study with long-term follow up. BMC Veterinary Research 11 ,228
  4. Engel O, Masic A, Landsberg G et al. (2018) Imepitoin shows benzodiazepine-like effects in models of anxiety. Frontiers in Pharmacology 9, 1225 
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  5. Engel O, von Klopmann T, Maiolini A et al. (2017) Imepitoin is well tolerated in healthy and epileptic cats. BMC Veterinary Research 13, 172 
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  6. Forster B, Engel O, Erhard M and Bartels A (2020) Short-term imepitoin treatment reduces stress level in dogs with generalized anxiety disorder. Journal of Veterinary Behavior 38, 67–73
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  7. McPeake KJ and Mills DS (2017) The use of imepitoin (Pexion™) on fear and anxiety related problems in dogs – a case series. BMC Veterinary Research 13, 173
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  8. Perdew I, Emke C, Johnson B et al. (2021) Evaluation of Pexion®(imepitoin) for treatment of storm anxiety in dogs: A randomised, double-blind, placebo-controlled trial. Veterinary Record 188, e18
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  9. Royaux E, Bhatti S, De Cock H et al. (2016) Cutaneous adverse drug reaction in a dog associated with imepitoin.Veterinary Dermatology 27, 118–121
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  10. Tipold A, Keefe TJ, Löscher W et al. (2015) Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs.Journal of Veterinary Pharmacology and Therapeutics 38, 160–168
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