1887

Levetiracetam (S-Etiracetam)

This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition
  1. Bailey KS, Dewey CW, Boothe DM et al. (2008) Levetiracetam as adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy. Journal of American Veterinary Medical Association 232, 867–872
  2. Beasley MJ and Boothe DM (2012) The pharmacokinetics of single dose extended release Keppra® with and without food in healthy adult dogs (abst). Journal of Veterinary Internal Medicine 26, 819
  3. Cagnotti G, Odore R, Gardini G et al. (2018) Pharmacokinetics of rectal levetiracetam as add-on treatment in dogs affected by cluster seizures or status epilepticus. BMC Veterinary Research 14, 189
  4. Charalambous M, Muñana K, Patterson EE et al. (2024) ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats. Journal of Veterinary Internal Medicine 38, 19–40
  5. Erath RE, Nessler JN, Riese F et al. (2020) Behavioural changes under levetiracetam treatmnet in dogs. Frontiers in Veterinary Science 7, 169
  6. Fredsø N, Sabers A, Toft N et al. (2016) A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy. Veterinary Journal 208, 44–49
  7. Green S and Olby N (2021) Levetiracetam-responisive paroxysmal exertional dyskinesia in a Welsh Terrier. Journal of Veterinary Internal Medicine 35, 1093–1097
  8. Hardy BT, Patterson EE, Cloyd JM et al. (2012) Double-masked, placebo-controlled study of intravenous levetiracetam for the treatment of status epilepticus and acute repetitive seizures in dogs. Journal of Veterinary Internal Medicine 26, 334–340
  9. Hazenfratz M and Taylor SM (2018) Recurrent seizures in cats: Treatment - which antiepileptic drugs are recommended? Journal of Feline Medicine and Surgery 20, 825–834
  10. Kelly D, Raimondi F and Shihab N (2017) Levetiracetam monotherapy for treatment of structural epilepsy in dogs: 19 cases (2010–2015). Veterinary Record 181, 401
  11. Linder J, Mehra J, Miller S et al. (2024) Use of levetiracetam for the successful treatmnet of suspected myoclonic seizures: five dogs (2016 - 2022). Journal of Small Animal Practice 65, 402–408
  12. Lowrie M, Thomson S, Bessant C et al. (2017) Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open-label study. Journal of Feline Medicine and Surgery 19, 200–206
  13. Moore S, Muñana KR, Papich MG and Nettifee-Osborne JA (2011) The pharmacokinetics of levetiracetam in healthy dogs concurrently receiving phenobarbital. Journal of Veterinary Pharmacology and Therapeutics 34, 31–34
  14. Muñana KR (2013) Management of refractory epilepsy. Topics in Companion Animal Medicine 28, 67–71
  15. Muñana KR, Thomas WB, Inzana KD et al. (2012) Evaluation of levetiracetam as adjunctive treatment for refractory canine epilepsy: a randomized, placebo-controlled crossover trial. Journal of Veterinary Internal Medicine 26, 341–348
  16. Packer RM, Nye G, Porter SE and Volk HA (2015) Assessment into the usage of levetiracetam in a canine epilepsy clinic. BMC Veterinary Research 11, 25
  17. Patterson EE, Goel V, Cloyd JC et al. (2008) Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokinetics. Journal of Veterinary Pharmacology and Therapeutics 31, 253–258
  18. Rohn K and Tipold A (2020) Behavioral changes under levetiracetam treatment in dogs. Frontiers in Veterinary Science 7, 169
  19. Saint-Maxen M, Juette T, Parent J et al (2024) Factors influencing serum concentration of levetiracetam in dogs with epilepsy. Journal of Veterinary Internal Medicine 38, 2249–2256
  20. Volk HA, Matiasek LA, Feliu-Pascual AL et al. (2008) The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs. Veterinary Journal 176, 310–319
  21. Wielaender F, James FMK, Cortez MA et al. (2018) Absence seizures as a feature of juvenile myoclonic epilepsy in Rhodesian Ridgeback dogs. Journal of Veterinary Internal Medicine 32, 428–423
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