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  3. Maropitant
Maropitant
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Maropitant

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This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition. 
  1. de la Puente-Redondo VA, Siedek EM, Benchaoui HA et al.(2007) The anti-emetic efficacy of maropitant (Cerenia) in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe.Journal of Small Animal Practice 48, 93–98
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  2. Hickman MA, Cox SR, Mahabir S et al.(2008) Safety, pharmacokinetics and use of the novel NK-1 receptor antagonist maropitant (Cerenia) for the prevention of emesis and motion sickness in cats.Journal of Veterinary Pharmacology and Therapeutics  31, 220–229
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  3. Kinobe RT and Miyake Y (2020) Evaluating the anti-inflammatory and analgesic properties of maropitant: A systematic review and meta-analysis.The  Veterinary Journal 259–260, 105471
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  4. Benchaoui HA, Siedek EM, De La Puente-Redondo VA et al. (2007) Efficacy of maropitant for preventing vomiting associated with motion sickness in dogs.Veterinary Record 161, 444–447
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  5. Burke JE, Hess RS and Silverstein DC (2021) Effectiveness of orally administered maropitant and ondansetron in preventing preoperative emesis and nausea in healthy dogs premedicated with a combination of hydromorphone, acepromazine, and glycopyrrolate.Journal of the American Veterinary Medical Association 260, S40 – S45
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  6. Chi TT and Hay Kraus BL (2020) The effect of intravenous maropitant on blood pressure in healthy awake and anesthetized dogs.PLoS One 15, e0229736
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  7. Conder GA, Sedlacek HS, Boucher JF and Clemence RG (2008) Efficacy and safety of maropitant, a selective neurokinin 1 receptor antagonist, in two randomized clinical trials for prevention of vomiting due to motion sickness in dogs.Journal of Veterinary Pharmacology and Therapeutics 31, 528–532
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  8. Corrêa JMX, Soares PCLR, Niella RV et al. (2019) Evaluation of the Antinociceptive Effect of Maropitant, a Neurokinin-1 Receptor Antagonist, in Cats Undergoing Ovariohysterectomy.Veterinary Medicine International 2019, 9352528
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  9. de la Puente-Redondo VA, Tilt N, Rowan TG and Clemence RG (2007) Efficacy of maropitant for treatment and prevention of emesis caused by intravenous infusion of cisplatin in dogs.American Journal of Veterinary Research 68, 48–56
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  10. Deckers N, Ruigrok CA, Verhoeve HP and Lourens N (2018) Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs.Veterinary Record Open 5, e000262
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  11. Hay Kraus BL (2014) Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs.Journal of the American Veterinary Medical Association 245, 1015–1020
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  12. Hay Kraus BL (2017) Spotlight on the perioperative use of maropitant citrate.Veterinary Medicine: Research and Reports  8, 41–51
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  13. Kantyka ME, Meira C, Bettschart-Wolfensberger R, Hartnack S and Kutter APN (2020) Prospective, controlled, blinded, randomized crossover trial evaluating the effect of maropitant versus ondansetron on inhibiting tranexamic acid-evoked emesis.Journal of Veterinary Emergency and Critical Care (San Antonio) 30, 436–441
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  14. Karna SR, Chambers P, Singh P, Lopez-Villalobos N and Kongara K (2022) Evaluation of analgesic interaction between morphine, maropitant and dexmedetomidine in dogs undergoing ovariohysterectomy.New Zealand Veterinary Journal 70, 10–21
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  15. Kenward H, Elliott J, Lee T and Pelligand L (2017) Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study.BMC Veterinary Research 13, 244
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  16. Lesman SP, Boucher JF, Grover GS et al. (2013) The pharmacokinetics of maropitant citrate dosed orally to dogs at 2 mg/kg and 8 mg/kg once daily for 14 days consecutive days. Journal of Veterinary Pharmacology and Therapeutics 36, 462–470
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  17. Lorenzutti AM, Martín-Flores M, Litterio NJ et al.(2016) Evaluation of the antiemetic efficacy of maropitant in dogs medicated with morphine and acepromazine.Veterinary Anaesthesia and Analgesia 43, 195–198
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  18. Lorenzutti AM, Martín-Flores M, Litterio NJ et al. (2017) A comparison between maropitant and metoclopramide for the prevention of morphine-induced nausea and vomiting in dogs.The Canadian Veterinary Journal  58, 35–38
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  19. Maina E and Fontaine J (2019) Use of maropitant for the control of pruritus in non-flea, non-food-induced feline hypersensitivity dermatitis: an open-label, uncontrolled pilot study.Journal of Feline Medicine and Surgery 21, 967–972
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  20. Martin-Flores M, Mastrocco A, Lorenzutti AM et al.(2017) Maropitant administered orally 2-2.5 h prior to morphine and dexmedetomidine reduces the incidence of emesis in cats.Journal of Feline Medicine and Surgery 19, 876–879
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  21. Martin-Flores M, Sakai DM, Learn MM et al. (2016) Effects of maropitant in cats receiving dexmedetomidine and morphine.Journal of the American Veterinary Medical Association 248, 1257–1261
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  22. Mason SL, Grant IA, Elliott J et al.(2014) Gastrointestinal toxicity after vincristine or cyclophosphamide administered with or without maropitant in dogs: a prospective randomised controlled study.Journal of Small Animal Practice 55, 391–398
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  23. Moyer AL, McKee TS, Bergman PJ and Vinayak A (2021) Low incidence of postoperative nausea, vomiting, regurgitation, and aspiration pneumonia in geriatric dogs receiving maropitant, famotidine, and fentanyl as part of an anesthesia protocol.Journal of the American Veterinary Medical Association 260, S46–S51
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  24. Narishetty ST, Galvan B, Coscarelli E et al.(2009) Effect of refrigeration of the antiemetic Cerenia (maropitant) on pain on injection.Veterinary Therapeutics 10, 93–102
    25.
  25. Ozawa SM, Hawkins MG, Drazenovich TL, Kass PH and Knych HK (2019) Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus).American Journal of Veterinary Research 80, 963–968
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  26. Quimby JM, Brock WT, Moses K et al. (2015) Chronic use of maropitant for the management of vomiting and inappetence in cats with chronic kidney disease: a blinded, placebo-controlled clinical trial.Journal of Feline Medicine and Surgery 17, 692–697
    27.
  27. Ramsey DS, Kincaid K, Watkins JA et al. (2008) Safety and efficacy of injectable and oral maropitant, a selective neurokinin 1 receptor antagonist, in a randomized clinical trial for treatment of vomiting in dogs.Veterinary Pharmacology and Therapeutics  31, 538–543
    28.
  28. Rau SE, Barber LG and Burgess KE (2008) Efficacy of maropitant in the prevention of delayed vomiting associated with administration of doxorubicin to dogs.Journal of Veterinary Internal Medicine 24, 1452–1457
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  29. Sedlacek HS, Ramsey DS, Boucher JF et al.(2018) Comparative efficacy of maropitant and selected drugs in preventing emesis induced by centrally or peripherally acting emetogens in dogs.Veterinary Pharmacology and Therapeutics  31, 533–537
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  30. Soares PCLR, Corrêa JMX, Niella RV et al.(2021) Continuous Infusion of Ketamine and Lidocaine Either with or without Maropitant as an Adjuvant Agent for Analgesia in Female Dogs Undergoing Mastectomy.Veterinary Medicine International 2021, 4747301
    31.
  31. Sullivan LA, Lenberg JP, Boscan P et al. (2018) Assessing the efficacy of maropitant versus ondansetron in the treatment of dogs with parvoviral enteritis.Journal of the American Animal Hospital Association 54, 338–343
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  32. Swallow A, Rioja E, Elmer T and Dugdale A (2017) The effect of maropitant on intraoperative isoflurane requirements and postoperative nausea and vomiting in dogs: a randomized clinical trial.Veterinary Anaesthesia and Analgesia 44, 785–793
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  33. Vail DM, Rodabaugh HS, Conder GA, Boucher JF and Mathur S (2007) Efficacy of injectable maropitant (CereniaTM) in a randomized clinical trial for prevention and treatment of cisplatin-induced emesis in dogs presented as veterinary patients.Veterinary and Comparative Oncology 5, 38–46
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  34. Yalcin E and Keser GO (2017) Comparative efficacy of metoclopramide, ondansetron and maropitant in preventing parvoviral enteritis-induced emesis in dogs. Veterinary Pharmacology and Therapeutics 40, 599–603
    35.
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