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Phenobarbital (Phenobarbitone)
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This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition.
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Alcoverro E, Tabar MD, Lloret A et al. (2014) Phenobarbital-responsive sialadenosis in dogs: case series. Topics in Companion Animal Medicine 29, 109–112
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Bersan E, Volk HA, Ros C and De Risio L (2014) Phenobarbitone-induced haematological abnormalities in idiopathic epileptic dogs: prevalence, risk factors, clinical presentation and outcome. Veterinary Record 175, 247
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Bhati SFM, De Rision L, Munana K et al. (2015) International veterinary task force consensus proposal: medical treatment of canine epilepsy in Europe. BMC Veterinary Research 11, 176
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Bunch SE (1993) Hepatotoxicity associated with pharmacologic agents in dogs and cats. Veterinary Clinics of North America: Small Animal Practice 23, 659–670
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Charalambous M, Brodbelt D and Volk HA (2014) Treatment in canine epilepsy – a systematic review. BMC Veterinary Research 10, 257
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Charalambous M, Muñana K, Patterson EE et al. (2024) ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats. Journal of Veterinary Internal Medicine 38, 19–40
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Charalambous M, Pakozdy A, Bhatti SFM and Volk HA (2018) Systematic review of antiepileptic drugs' safety and effectiveness in feline epilepsy. BMC Veterinary Research 14, 64
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Charalambous M, Shivapour SK, Brodbelt DC and Volk HA (2016) Antiepileptic drugs' tolerability and safety - a systematic review and meta-analysis of adverse effects in dogs. BMC Veterinary Research 12, 79
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Dohany A, Guija-de-Arespacochaga A, Fux D et al. (2023) A retrospective evaluation of phenobarbital-induced hematologic changes in 69 cats. Veterinary Clinical Pathology 52, 601–606
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Farnbach GC (1984) Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. Journal of the American Veterinary Medical Association 184, 1117–1120
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Finnerty KE, Barnes Heller HL, Mercier MN et al. (2014) Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004–2013). Journal of the American Veterinary Medical Association 244, 195–199
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Hermans M, Charalambous M, Pakozdy A et al. (2022) Evaluation of the effect of phenobarbital administration on the biochemistry profile, with focus on serum liver values, in epileptic cats. Journal of Feline Medicine and Surgery 24, 530–538
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Lampe R, Manens J and Sharp N (2017) Suspected phenobarbital-induced pseudolymphoma in a dog. Journal of Veterinary Internal Medicine 231, 1858–1859
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Liatis T and Cherubini GB (2021) Hypersexuality responsive to phenobarbital in a male neutered domestic shorthair cat. Journal of Veterinary Behavior 41, 7–11
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Marsh O, Corsini G, Van Dijk J, Gutierrez-Quintana R and De Risio L (2021) Prevalence and clinical characteristics of phenobarbitone-associated adverse effects in epileptic cats. Journal of Feline Medicine and Surgery 23, 59–66
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Muñana KR, Nettifee-Osborne JA and Papich MG (2015) Effect of chronic administration of phenobarbital, or bromide, on pharmacokinetics of levetiracetam in dogs with epilepsy. Journal of Veterinary Internal Medicine 29, 614–619
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Phillips E, Kornya M, Collier A et al. (2023) Presumptive phenobarbital-induced systemic lupus erythematosus in a domestic dog. Journal of Veterinary Internal Medicine 37, 2482–2487
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Scott TN, Bailin HG, Jutkowitz LA et al. (2021) Bone marrow, blood, and clinical findings in dogs treated with phenobarbital. Veterinary Clinical Pathology 50, 122–131
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Stabile F, van Dijk J, Barnett CR et al. (2019) Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy. Veterinary Journal 249, 53–57
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Watanangura A, Meller S, Suchodolski JS et al. (2022) The effect of phenobarbital treatment on behavioral comorbidities and on the composition and function of the fecal microbiome in dogs with idiopathic epilepsy. Frontiers in Veterinary Science 9, 933905