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  3. Zoledronate (Zoledronic acid)
Zoledronate (Zoledronic acid)
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Zoledronate (Zoledronic acid)

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This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition. 
  1. Brewer DJ, Macfarlane M, O'Connel E and Bacon NJ (2022) Toxicity of zoledronic acid after intravenous administration: a retrospective study of 95 dogs. Journal of Veterinary Internal Medicine 36, 253–258
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  2. Fan TM, de Lorimier LP, Garrett LD and Lacoste HI (2008) The bone biologic effects of zoledronate in healthy dogs and dogs with malignant osteolysis. Journal of Veterinary Internal Medicine 22, 380–387
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  3. de Lorimier LP and Fan TM (2005) Bone metabolic effects of single-dose zoledronate in healthy dogs. Journal of Veterinary Internal Medicine 19 , 924–927
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  4. Lundberg AP, Hoang CT, Billhymer A and Selting KA (2022) Combining radiation therapy with zoledronate for the treatment of osteo‐invasive feline oral squamous cell carcinoma. Veterinary and Comparative Oncology 20, 788–796
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  5. Major PP and Coleman RE (2001) Zoledronic acid in the treatment of hypercalcemia of malignancy: results of the international clinical development program. Seminars in Oncology 28(2 Suppl 6), 17–24
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  6. Norquest CJ, Rogic A, Gimotty PA et al. (2024) Effects of neoadjuvant zoledronate and radiation therapy on cell survival, cell cycle distribution, and clinical status in canine osteosarcoma. Frontiers in Veterinary Science 11, 1237084
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  7. Santini D, Fratto ME, Vincenzi B et al. (2006) Zoledronic acid in the management of metastatic bone disease. Expert Opinion in Biological Therapeutics 6, 1333–1348
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  8. Schenk A, Lux C, Lane J and Martin O (2018) Evaluation of zoledronate as treatment for hypercalcemia in four dogs. Journal of the American Animal Hospital Association 54, e54604
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  9. Smith AA, Lindley SES, Almond GT et al. (2023) Evaluation of zoledronate for the treatment of canine stage III osteosarcoma: a phase II study. Veterinary Medicine and Science 9, 59–67
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  10. Spugnini EP, Vincenzi B, Caruso G et al. (2009) Zoledronic acid for the treatment of appendicular osteosarcoma in a dog. Journal of Small Animal Practice 50 , 44–46
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  11. Wypij JM, Fan TM, Fredrickson RL et al. (2008) In vivo and in vitro efficacy of zoledronate for treating oral squamous cell carcinoma in cats. Journal of Veterinary Internal Medicine 22, 158–163
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