1887

Zonisamide

This is a drug monograph from the BSAVA Small Animal Formulary Part A: Canine and Feline. BSAVA members should login for access to the full monograph. Non-members can join BSAVA, buy a Formulary subscription, or buy the printed edition
  1. Ackermann AL, Frank LA, McEntee MF and May ER (2015). Erythema multiforme assosiated with zonisamide in a dog. Veterinary Dermatology 26, 391–392
  2. Boothe DM, Perkins J and Dewey C (2005) Clinical pharmacokinetics and safety of the anticonvulsant zonisamide in healthy dogs following single and multiple dosing. Proceedings of the 23rd ACVIM forum, Baltimore, USA
  3. Brandifino M, Sinnott-Stutzman V, Sisson A and Whelan M (2022) Presumed zonisamide-induced blood dyscrasias in four dogs. Journal of Veterinary Emergency and Critical Care 32, 805–811
  4. Brewer DM, Cerda-Gonzalez S, Dewey CW et al. (2014) Pharmacokinetics of single-dose rectal zonisamide administration in normal dogs. Journal of Veterinary Internal Medicine 29, 603–606
  5. Budsberg SC (2004) Zonisamide therapy for refractory idiopathic epilepsy in dogs. Journal of the American Animal Hospital Association 40, 285–291
  6. Chung JY, Hwang CY, Chae JS et al. (2012) Zonisamide monotherapy for idiopathic epilepsy in dogs. New Zealand Veterinary Journal 60 , 357–359
  7. Cook AK, Allen AK, Espinosa D and Barr J (2011) Renal tubular acidosis associated with zonisamide therapy in a dog. Journal of Veterinary Internal Medicine 25, 1454–1457
  8. Dewey CW, Guiliano R, Boothe DM et al. (2004) Zonisamide therapy for refractory idiopathic epilepsy in dogs. Journal of the American Animal Hospital Association 40, 285–291
  9. Djani DM, Liou M, Aravamuthan S, Lau V and Cameron S (2024) A retrospective study on the efficay of zonisamide in controlling seizures in 57 cats. Journal of Veterinary Internal Medicine 38, 1092–1100
  10. Gadde KM, Franciscy DM, Wagner HR 2nd and Krishnan KR (2003) Zonisamide for weight loss in obese adults: a randomized controlled trial. Journal of the American Medical Association 289, 1820–1825
  11. Hasegawa D, Kobayashi M, Kuwabara T et al. (2008) Pharmacokinetics and toxicity of zonisamide in cats. Journal of Feline Medicine and Surgery 10, 418–421
  12. Kanazono S, Ukai M and Hiramoto A (2021) Abnormal behavioural episodes associated with zonisamide in three dogs: a case report. Frontiers in Veterinary Science 8, 763822
  13. von Klopmann T, Rambeck B and Tipold A (2007) A study of zonisamide therapy for refractory idiopathic epilepsy in dogs. Journal of Small Animal Practice 48 , 134–138
  14. Miller ML, Center SA, Randolph JF et al. (2011) Apparent acute idiosyncratic hepatic necrosis associated with zonisamide administration in a dog. Journal of Veterinary Internal Medicine 25, 1156–1160
  15. Orito K, Saito M, Fukunaga K et al. (2008) Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogs. Journal of Veterinary Pharmacology and Therapeutics 31, 259–264
  16. Saito M, Nomura A, Hasegawa D et al. (2024) Clinical efficacy and tolerability of zonisamide monotherapy in dogs with newly diagnosed idiopathic epilepsy: Prospective open - label uncontrolled multicenter trial. Journal of Veterinary Internal Medicine 38, 2228–2236
  17. Schwartz M, Muñana KR and Olby NJ (2011) Possible drug-induced hepatopathy in a dog receiving zonisamide monotherapy for treatment of cryptogenic epilepsy. Journal of Veterinary Medical Scie nce 73, 1505–1508
  18. Smith TK, Cameron S, Trepanier LA (2022) Incidence of hepatopathies in dogs administered zonisamide orally: a retrospective study of 384 cases. Journal of Veterinary Medical Scie nce 36, 576–579
  19. Walker RM, DiFonzo CJ, Barsoum NJ et al. (1988) Chronic toxicity of the anticonvulsant zonisamide in beagle dogs. Fundamental and applied Toxicology 11, 333–342
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